Okada, Satoshi; Takayasu, Satoko; Tomita, Shunsuke; Suzuki, Yoshio; Yamamoto, Shinya published an article in 2020, the title of the article was Development of neutral pH-responsive microgels by tuning cross-linking conditions.Safety of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) And the article contains the following content:
Polymer microgels that respond in a range of neutral pH can be useful for the development of mol. imaging tools and drug-delivery carriers. Here, we describe a simple approach in developing microgels that undergo volume phase transitions and substantial NMR (NMR) relaxometric changes within a narrow pH range of 6.4 to 7.4. The pH-responsive microgels were synthesized using methacrylic acid and a series of ethylene glycol dimethacrylate cross-linkers with repeating units of ethylene glycol that range from one to four. NMR relaxometry demonstrated that the transverse relaxation time (T2) of a suspension containing microgels that were cross-linked with diethylene glycol dimethacrylate sharply decreases at the pH where volume phase transition occurs. The polymer microgels cross-linked with 40 and 45 mol% of diethylene glycol dimethacrylate caused about 50% T2 reduction with decreasing pH from 6.8 to 6.4. These results demonstrated that responses of microgels to a range of neutral pH can be easily tuned by using appropriate cross-linkers with certain crosslinking degree. This approach can be useful in developing highly sensitive mol. sensors for magnetic resonance imaging (MRI) of tissue pH values. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Safety of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)
The Article related to development neutral ph responsive microgel tuning crosslinking condition, mri, nmr relaxation time, ph-responsive microgels, volume phase transition, Pharmaceuticals: Formulation and Compounding and other aspects.Safety of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)
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