On February 6, 2018, Obata, Shunsuke; Asamitsu, Sefan; Hashiya, Kaori; Bando, Toshikazu; Sugiyama, Hiroshi published an article.Formula: C13H14N2O8 The title of the article was G-Quadruplex Induction by the Hairpin Pyrrole-Imidazole Polyamide Dimer. And the article contained the following:
The G-quadruplex (G4) is one type of higher-order structure of nucleic acids and is thought to play important roles in various biol. events such as regulation of transcription and inhibition of DNA replication. Pyrrole-imidazole polyamides (PIPs) are programmable small mols. that can sequence-specifically bind with high affinity to the minor groove of double-stranded DNA (dsDNA). Herein, we designed head-to-head hairpin PIP dimers and their target dsDNA in a model G4-forming sequence. Using an electrophoresis mobility shift assay and transcription arrest assay, we found that PIP dimers could induce the structural change to G4 DNA from dsDNA through the recognition by one PIP dimer mol. of two duplex-binding sites flanking both ends of the G4-forming sequence. This induction ability was dependent on linker length. This is the first study to induce G4 formation using PIPs, which are known to be dsDNA binders. The results reported here suggest that selective G4 induction in native sequences may be achieved with PIP dimers by applying the same design strategy. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Formula: C13H14N2O8
The Article related to hairpin pyrrole imidazole polyamide dimer dna transition g quadruplex, General Biochemistry: Nucleic Acids and Their Constituents and other aspects.Formula: C13H14N2O8
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics