Li, Xin; He, Songtao; Song, Qiuling published an article in 2020, the title of the article was Enantio- and diastereoselective diarylmethylation of 1,3-dicarbonyl compounds.Category: esters-buliding-blocks And the article contains the following content:
A Cu-catalyzed enantio- and diastereoselective diarylmethylation of 1,3-dicarbonyl compounds RC(O)CH(R1)C(O)R2 (R = Et, 4-methoxyphenyl, cyclohexyl, thiophen-2-yl, etc.; R1 = H, Me; R2 = Me, OMe, OEt, O(i-Pr); RR1 = -(CH2)3-, -(CH2)4-, -(CH2)2O-) and Me 1-oxo-2-indancarboxylate is described. It is a successful example of constructing all-carbon quaternary stereocenters from 3°C-H nucleophiles, a challenging topic in synthetic chem. In the present work, two contiguous stereocenters I (R3 = R4 = Me, t-Bu, i-Pr, TMS, Ph; R3 = Me, R4 = t-Bu; Ar = naphthalen-2-yl, 1-benzofuran-2-yl, 2,3-dihydro-1,4-benzodioxin-6-yl, thiophen-2-yl, etc.) are constructed with high levels of stereoselectivity and atom economy. The broad scope of 1,3-dicarbonyl nucleophiles and the tolerance of a wide range of functional groups make this protocol of great importance in the synthesis of chiral diarylmethane compounds I. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Category: esters-buliding-blocks
The Article related to chiral diarylmethane preparation enantioselective diastereoselective, dicarbonyl compound quinone methide diarylmethylation copper indenooxazole catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Category: esters-buliding-blocks
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