On March 20, 2008, Koppel, Gary A.; Chaney, Michael O. published a patent.Product Details of 53838-27-0 The title of the patent was Preparation of β-lactamylalkanoic acids as cannabinoid receptor modulators. And the patent contained the following:
Substituted 2-(azetidin-2-on-1-yl)alkanoic acids, alkanedioic acids, 2-hydroxyalkyl and 2-acyl alkanoic acids, e.g., I [R4 = substituted phenylethenyl; X = (CH2)n; n = 1-2; A = OH, NH2 and derivatives; or A is taken together with the attached CO group to form an ester; A’ = OH, NH2 and derivatives; or A’ is taken together with the attached CO group to form an ester], were prepared as cannabinoid-1 (CB1) and/or cannabinoid-2 (CB2) receptor modulators for treating disease states associated with and responsive to modulation of the CB1 and/or CB2 receptor activity. modulators. Pharmaceutical compositions containing I are described. Thus, II was prepared, and had IC50 value of < 10 μM and about 1 μM in CB1 and CB2 binding assays on cells. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Product Details of 53838-27-0
The Article related to lactamylalkanoic acid preparation cannabinoid receptor modulator, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Product Details of 53838-27-0
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics