On May 19, 2020, Huang, Penghsuan; Huang, Chun-Ying; Lin, Ta-Chun; Lin, Li-En; Yang, Ethan; Lee, Chuping; Hsu, Cheng-Chih; Chou, Pi-Tai published an article.Quality Control of Methyl N-Methylanthranilate The title of the article was Toward the Rational Design of Universal Dual Polarity Matrix for MALDI Mass Spectrometry. And the article contained the following:
A series of novel anthranilic acid derivatives I-IV, of which COOH-NH2 (I) and COOH-NHMe (IV) are endowed with acid and base bifunctionality, were designed and synthesized for matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications in dual polarity mol. imaging of biol. samples, particularly for lipids. The heat of protonation, deprotonation, and proton transfer reaction as well as the capability of analyzing biomols. in both pos. and neg. ion modes for I-IV were systematically investigated under standard 355 nm laser excitation. The results indicate correlation between dual polarity and acid-base property. Further, COOH-NHMe (IV) showed a unique performance and was successfully applied as the matrix for MALDI-TOF mass spectrometry imaging (MSI) for studying the mouse brain. Our results demonstrate the superiority of COOH-NHMe (IV) in detecting more lipid and protein species compared to com. available matrixes. Moreover, MALDI-TOF MSI results were obtained for lipid distributions, making COOH-NHMe (IV) a potential next generation universal matrix. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Quality Control of Methyl N-Methylanthranilate
The Article related to universal dual polarity matrix maldi mass spectrometry, Biochemical Methods: Spectral and Related Methods and other aspects.Quality Control of Methyl N-Methylanthranilate
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