On March 31, 2018, Hoellerer, Christine; Becker, Guenther; Goeen, Thomas; Eckert, Elisabeth published an article.Electric Literature of 3319-31-1 The title of the article was Regioselective ester cleavage of di-(2-ethylhexyl) trimellitates by porcine liver esterase. And the article contained the following:
In a comparative study the ester hydrolysis of the plasticizers di-(2-ethylhexyl) phthalate (DEHP) and tri-(2-ethylhexyl) trimellitate (TEHTM) as well as of the diester isomers 1,2-di-(2-ethylhexyl) trimellitate (1,2-DEHTM), 1,4-di-(2-ethylhexyl) trimellitate (1,4-DEHTM) and 2,4-di-(2-ethylhexyl) trimellitate (2,4-DEHTM) was investigated by a newly developed in vitro exptl. using porcine liver esterase (PLE). The substrates were incubated with PLE for 48 h at 25° in borate buffer and samples were taken at predetermined intervals during the experiment The samples were processed using liquid-liquid extraction and analyzed using LC-MS/MS. The results demonstrated a rapid and extensive hydrolysis of the diester DEHP to the monoester mono-(2-ethylhexyl) phthalate (MEHP) during the incubation with PLE. The isomers of DEHTM were also hydrolyzed by PLE to a high extent, whereas TEHTM showed a high stability against enzymic hydrolysis. The regioselective anal. revealed that the monoester isomers 1-MEHTM and 2-MEHTM were predominantly produced during the degradation of DEHTM isomers, indicating a preferred hydrolysis at the para-position. These findings are eminent for planning further investigations on the human TEHTM metabolism, as the extent, rate and route of metabolism are of crucial importance for a toxicol. assessment. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Electric Literature of 3319-31-1
The Article related to pig liver esterase dehp tehtm dehtm, di-(2-ethylhexyl) phthalate, metabolism, porcine liver esterase, tri-(2-ethylhexyl) trimellitate, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Electric Literature of 3319-31-1
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