On July 31, 2014, Guo, Rongyun; Nie, Yao; Mu, Xiao Qing; Xu, Yan; Xiao, Rong published an article.Application In Synthesis of (R)-Methyl 3-hydroxybutanoate The title of the article was Genomic mining-based identification of novel stereospecific aldo-keto reductases toolbox from Candida parapsilosis for highly enantioselective reduction of carbonyl compounds. And the article contained the following:
Biocatalytic reduction of prochiral ketones offers significant potential in synthesis of optically active alcs. However, so far the application of aldo-keto reductases (AKRs) in asym. reduction has been hampered due to limited availability of AKRs with high enantioselectivity and catalytic efficiency. Based on the genome sequence of Candida parapsilosis, a versatile bioresource for asym. reduction, eight open reading frames encoding putative AKRs were discovered and expressed, and the resulted enzymes (CPARs), comprising an AKR toolbox, were evaluated toward various carbonyl substrates. The CPARs were active to the selected substrates, especially 2-hydroxyacetophenone and Et 4-chloro-3-oxobutyrate. Addnl., most of them were obviously enantioselective to the substrates and gave alc. products with optical purity up to 99% e.e. Of the enzymes, CPAR4 was outstanding with excellent enantioselectivity and broad substrate spectrum. All these pos. features demonstrate that genomic mining is powerful in searching for novel and efficient biocatalysts of desired reactions for pharmaceuticals and fine chems. synthesis. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Application In Synthesis of (R)-Methyl 3-hydroxybutanoate
The Article related to candida genomics aldo keto reductase enantioselectivity reduction keton, Enzymes: Separation-Purification-General Characterization and other aspects.Application In Synthesis of (R)-Methyl 3-hydroxybutanoate
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