On February 28, 2017, Genay, Stephanie; Feutry, Frederic; Masse, Morgane; Barthelemy, Christine; Sautou, Valerie; Odou, Pascal; Decaudin, Bertrand; Azaroual, Nathalie; Armed Study Group published an article.Electric Literature of 3319-31-1 The title of the article was Identification and quantification by 1H nuclear magnetic resonance spectroscopy of seven plasticizers in PVC medical devices. And the article contained the following:
Medical devices are generally made of polyvinyl chloride plasticized by six authorized plasticizers as alternatives to di-(2-ethylhexyl)-phthalate (DEHP) classified as reprotoxic class 1b. These are acetyl tri-Bu citrate (ATBC), di-(2-ethylhexy) adipate (DEHA), di-(2-ethylhexyl) terephthalate (DEHT), di-isononyl cyclohexane-1,2-dicarboxylate (DINCH), di-isononyl phthalate (DINP), and tri-octyl trimellitate (TOTM). The main objective of this study was to propose a new method using 1H NMR spectroscopy to determine and quantify these seven plasticizers in PVC sheets, standard infusion tubings, and com. available medical devices. Two techniques were compared: dissolution in deuterated THF and extraction by deuterated chloroform. Plasticizer 1H NMR spectra were very similar in both deuterated solvents; dissolution and extraction provided similar results. The sensitivity of this method enabled us to detect and quantify the presence of minor plasticizers in PVC. In nine com. available samples, the major plasticizer was identified and quantified by 1H NMR. In six samples, one, two, or three minor plasticizers were identified and also quantified. DEHP was detected in only one tubing. NMR is therefore very convenient for studying plasticizers contained in medical devices. Only small quantities of solvents and sample are required. It is not necessary to dilute samples to enter a quantification range, and it is sufficiently sensitive to detect contaminants. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Electric Literature of 3319-31-1
The Article related to quantification nmr spectroscopy plasticizer pvc medical device, biomaterials, medical devices, nuclear magnetic resonance, plasticizers, polymers, polyvinyl chloride, Biochemical Methods: Spectral and Related Methods and other aspects.Electric Literature of 3319-31-1
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics