Fan, Zhiping; Cheng, Ping; Liu, Min; Li, Dacheng; Liu, Guiqin; Zhao, Yanna; Ding, Zhuang; Chen, Fang; Wang, Bingquan; Tan, Xiaoxiao; Wang, Zhengping; Han, Jun published an article in 2017, the title of the article was Poly(glutamic acid) hydrogels crosslinked via native chemical ligation.Related Products of 6038-19-3 And the article contains the following content:
Mild crosslinking methods, which have a strong influence on biomedical hydrogels and scaffolds, have attracted wide attention in recent years. In this project, native chem. ligation (NCL) was utilized to prepare biocompatible and biodegradable hydrogels using naturally derived poly(glutamic acid) (PGA) with no additives or byproducts. Firstly, thiolactone-grafted poly(glutamic acid) (PGA-HC) and cysteine-grafted poly(glutamic acid) (PGA-C) precursors were synthesized. Their structure was confirmed by NMR (NMR). Then, hydrogels crosslinked by NCL were formed by blending buffered solutions of PGA-HC and PGA-C with no additives under physiol. conditions. After that, the equilibrium water content, morphol., degradation rate and mech. properties of the hydrogels were characterized in detail. The data showed that the PGA hydrogels had gelation times, water contents and mech. properties that were tunable by adjusting the precursor composition Furthermore, the biocompatibility of the hydrogels was confirmed by an MTT assay. These characteristics provide a potential opportunity for the NCL hydrogels as wound dressings, skin fillings, drug delivery vehicles and tissue regeneration matrixes. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Related Products of 6038-19-3
The Article related to polyglutamic acid hydrogen crosslinking chem ligation biomaterial, Pharmaceuticals: Prosthetics and Medical Goods and other aspects.Related Products of 6038-19-3
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