On August 10, 2021, Deng, Man; Liang, Xueyi; Du, Bibai; Luo, Dan; Chen, Hui; Zhu, Chunyou; Zeng, Lixi published an article.Quality Control of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate The title of the article was Beyond Classic Phthalates: Occurrence of Multiple Emerging Phthalate Alternatives and Their Metabolites in Human Milk and Implications for Combined Exposure in Infants. And the article contained the following:
Because of the recognized toxicity and legislative regulation of classic phthalates (PAEs), the manufacture and use of PAE alternatives have rapidly grown. However, lactational exposure to these emerging replacement chems. remains unknown. In this study, 11 classic PAEs, 14 emerging PAE alternatives, and 24 of their metabolites were comprehensively investigated in human milk from China. Except for nine detectable PAEs, nine of the 14 emerging PAE alternatives, including three (1,4-DEHCH, 1,2-DEHCH, and DEHIP) not reported before in the environment, were first identified and detected in human milk. Total concentrations of nine detectable PAE alternatives were in the range of 0.252-16.1 ng/mL, slightly lower than those of nine detectable PAEs (2.12-34.1 ng/mL). Addnl., 12 of the 24 target metabolites were found in human milk. Total concentrations (4.41-138 ng/mL) of these metabolites were significantly higher than those of their parent compounds Our findings highlighted the considerable coexistence of PAEs, emerging PAE alternatives, and their metabolites, resulting in a complex “cocktail” of plasticizers in human milk. Preliminary risk assessment indicated no or minor risk to breast-fed infants, but long-term low-level exposure to the “cocktail” chems. is of emerging concern. This is the first identification of multiple emerging PAE alternatives and their metabolites in human milk. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Quality Control of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
The Article related to phthalate metabolite human milk breastfeeding risk assessment china, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.Quality Control of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
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