Chavan, Subhash P.; Khatod, Harshali S.; Das, Tamal; Vanka, Kumar published an article in 2016, the title of the article was Exploration of the diastereoselectivity in an unusual Grignard reaction and its application towards the synthesis of styryl lactones 7-epi-(+)-goniodiol and 8-epi-(-)-goniodiol.Product Details of 872046-08-7 And the article contains the following content:
An unusual diastereoselective Grignard reaction is explored, where the Grignard reagents are derived from 1,n-dihaloalkanes. A steric bias due to the presence of a quaternary center adjacent to the acetonide ester at the benzylic position is responsible for the formation of an intramolecularly reduced product in almost quant. yield. This steric hindrance is responsible for the diastereoselectivity observed with a variety of aromatic as well as aliphatic esters. The unusual Grignard reaction furnishes long chain secondary alcs. possessing a terminal olefin, which are synthetically important intermediates. As an application of this method, the diastereoselective synthesis of styryl lactones viz. 7-epi-(+)-goniodiol (29) and 8-epi-(-)-goniodiol (30) has been achieved. The experimental process involved the reaction of Methyl 2-(2,6-difluorophenyl)acetate(cas: 872046-08-7).Product Details of 872046-08-7
The Article related to stereoselective grignard synthesis styryl lactone goniodiol, Carbohydrates: Alditols, Cyclitols, Glycerides and other aspects.Product Details of 872046-08-7
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics