On February 19, 2009, Castro Palomino Laria, Julio Cesar; Terricabras Belart, Emma; Erra Sola, Montserrat; Navarro Romero, Eloisa; Fonquerna Pou, Silvia; Cardus Figueras, Aranzazu; Lozoya Toribio, Maria Estrella published a patent.Recommanded Product: 141940-37-6 The title of the patent was Preparation of azabiphenylaminobenzoic acid derivatives as DHODH inhibitors. And the patent contained the following:
The title compounds I [R1 = H, halo, alkyl, etc.; R2 = H, halo, alkyl; R3 = CO2R5, CONHR5, tetrazolyl, SO2NHR5, CONHSO2R5 (wherein R5 = H, alkyl); R4 = H, alkyl; R9 = H, Ph; G1 = N, CR6 (R6 = H, halo, alkyl, etc.); G2 = H, OH, halo, cycloalkyl, etc.], useful as inhibitors of the dihydroorotate dehydrogenase (DHODH), were prepared and formulated. Thus, heating 2-amino-5-cyclopropylbenzoic acid with 5-bromo-2-phenylpyrimidine (preparations given) in the presence of Cu2O, Cu and K2CO3 in DME at 130°C afforded 57% II which showed IC50 of 105 nM against hDHODH. Pharmaceutical compositions comprising I, alone or in combination with other therapeutic agent, were disclosed. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Recommanded Product: 141940-37-6
The Article related to azabiphenylaminobenzoic acid preparation dihydroorotate dehydrogenase dhodh inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: 141940-37-6
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics