On January 8, 2015, Campos, Sebastien Andre; Harling, John David; Miah, Afjal Hussain; Smith, Ian Edward David published a patent.Computed Properties of 882518-89-0 The title of the patent was Benzothiophene derivatives as estrogen receptor inhibitors and their preparation and use for the treatment of diseases. And the patent contained the following:
The invention relates to benzothiophene derivatives of formula I, which are estrogen receptor inhibitors and which are useful in the treatment of diseases mediated by the estrogen receptor. Compounds of formula I wherein R1 is H, OH, C1-3 alkoxy and halo; R2 is OH and C1-3 alkoxy; X is O and CO; L is a linker; R3 is (un)branched C1-6 alkyl and C3-6 cycloalkyl; R4 is 4-methylthiazol-5-yl, oxazol-5-yl and halo; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their estrogen receptor alpha (ERa) degradation (data not given). The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).Computed Properties of 882518-89-0
The Article related to benzothiophene preparation estrogen receptor inhibitor treatment disease, Heterocyclic Compounds (One Hetero Atom): Thiophenes and other aspects.Computed Properties of 882518-89-0
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics