Bernard, Lise; Eljezi, Teuta; Clauson, Helene; Lambert, Celine; Bouattour, Yassine; Chennell, Philip; Pereira, Bruno; Sautou, Valerie; ARMED Study Group published an article in 2018, the title of the article was Effects of flow rate on the migration of different plasticizers from PVC infusion medical devices.Computed Properties of 3319-31-1 And the article contains the following content:
Infusion medical devices (MDs) used in hospitals are often made of plasticized polyvinylchloride (PVC). These plasticizers may leach out into infused solutions during clin. practice, especially during risk-situations, e.g multiple infusions in Intensive Care Units and thus may enter into contact with the patients. The migrability of the plasticizers is dependent of several clin. parameters such as temperature, contact time, nature of the simulant, etc. . . However, no data is available about the influence of the flow rate at which drug solutions are administrated. In this study, we evaluated the impact of different flow rates on the release of the different plasticizers during an infusion procedure in order to assess if they could expose the patients to more toxic amounts of plasticizers. Migration assays with different PVC infusion sets and extension lines were performed with different flow rates that are used in clin. practice during 1h, 2h, 4h, 8h and 24h, using a lipophilic drug simulant. From a clin. point of view, the results showed that, regardless of the plasticizer, the faster the flow rate, the higher the infused volume and the higher the quantities of plasticizers released, both from infusion sets and extension lines, leading to higher patient exposure. However, phys., there was no significant difference of the migration kinetics linked to the flow rate for a same medical device, reflecting complex interactions between the PVC matrix and the simulant. The migration was especially dependent on the nature and the composition of the medical device. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Computed Properties of 3319-31-1
The Article related to polyvinylchloride flow rate plasticizer migration infusion medical device, Pharmaceuticals: Prosthetics and Medical Goods and other aspects.Computed Properties of 3319-31-1
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