On April 30, 2015, Bai, Cui-Gai; Xu, Yin-Tong; Li, Ning-Ning; Wang, Jing-Han; Yang, Cheng; Chen, Yue; Zhou, Hong-Gang published an article.Product Details of 6038-19-3 The title of the article was Cysteine and Its Derivatives as New Delhi Metallo-beta-lactamase-1 Inhibitors. And the article contained the following:
Nearly all antibiotics are ineffective to the antibiotic-resistant bacteria New Delhi metallo-beta -lactamase-1(NDM-1), one of the most important reasons is that antibiotics can be hydrolyzed by NDM-1 in these bacteria. Up to date, Many compounds, including captopril, are found to possess NDM-1 inhibition activity. Herein we report that some cysteine derivatives or homocysteine derivatives can inhibit the NDM-1 protein, and the lead compound 9 has the inhibition of the NDM-1 protein with IC50 of 1 μM, which is about 8 times potency of captopril. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Product Details of 6038-19-3
The Article related to cysteine captopril antibiotic ndm1 inhibitor dosage regimen, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Product Details of 6038-19-3
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