Zhou, Zhifang; Ding, Wenzhang; Li, Chen; Wu, Zhimeng published an article in 2017, the title of the article was Synthesis and immunological study of a wall teichoic acid-based vaccine against E. faecium U0317.Safety of Bis(2,5-dioxopyrrolidin-1-yl) glutarate And the article contains the following content:
A repeat unit of cell wall teichoic acids (WTA) isolated from Enterococcus faecium U0317 was chem. synthesized efficiently by a stepwise strategy. It was derivatized with a 5-aminopentanyl linker to facilitate conjugation with carrier proteins KLH and HSA. Immunol. studies of the KLH conjugate demonstrated that it could provoke robust immune responses and high titers of IgG antibodies, which could successfully recognize the synthesized WTA repeat unit . This result suggested that synthetic glycoconjugate could be a promising vaccine candidate against E. faecium for further studies. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Safety of Bis(2,5-dioxopyrrolidin-1-yl) glutarate
The Article related to synthesis wall teichoic acid vaccine, Immunochemistry: Adjuvants, Antigens, Haptens, and Vaccines and other aspects.Safety of Bis(2,5-dioxopyrrolidin-1-yl) glutarate
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