On May 1, 2018, Yu, Sun-Chol; Ri, Dong-Myong; Kuhn, Hartmut published an article.Name: Phenyl Salicylate The title of the article was Hydrophobicity and glutathione peroxidase-like activity of substituted salicyloyl-5-seleninic acids: Re-investigations on aromatic selenium compounds based on their hydrophobicity. And the article contained the following:
Previously we have shown that some of 5-selenized salicylic acid derivatives exhibit glutathione peroxidase (GPx)-like activities higher than or equal to ebselen [Yu et al., Chem. Eur. J., 2008, 14, 7066; Organic Biomol. Chem., 2010, 8, 828]. For understanding the absence of GPx-like activity of the homolog of 5-seleninic anhydride of salicyloylglycine with a loger side chain, we have further synthesized 19 new derivatives (5-seleninic acids of Me or Ph salicylates, N-salicyloyl ω-carboxyalkylamines or N-salicyloyl alkyl/phenyl amines, and some of their diselenides). Some of the 5-seleninic acids which carry long side chains or cyclohexyl group have exerted no GPx-like activity, irresp. of whether they are derived from ω-carboxyalkylamines or simple alkylamines. Such lacks of GPx-like activity let us quant. relate the GPx-like activities of the congeners of the above 3 series with their hydrophobicity (ClogP), which showed satisfactory correlations in each series. The mol. hydrophobicity was then extensively applied to diverse known aromatic selenium GPx mimics including diaryl diselenides and ebselen derivatives to explain their GPx-like activities in comparably quant. mode, which could be helpful in designing new improved GPx mimic analogs in each series. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Name: Phenyl Salicylate
The Article related to hydrophobicity glutathione peroxidase like activity substituted salicyloylseleninic acid, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.Name: Phenyl Salicylate
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