On May 31, 2020, Yamamoto, Yusuke; Fujita, Masaharu; Wanibuchi, Sayaka; Sato, Ayako; Katsuoka, Yasuhiro; Kasahara, Toshihiko published an article.SDS of cas: 85-91-6 The title of the article was Development of photo-amino acid derivative reactivity assay: a novel in chemico alternative method for predicting photoallergy. And the article contained the following:
Photoallergy test of cosmetics and several types of pharmaceutical substances is often necessary for obtaining approval from authorities. However, there are no official test guidelines for photoallergy evaluation. Therefore, we tried to establish a photoallergy test by utilizing an in chemico alternative sensitization method, amino acid derivative reactivity assay (ADRA). To determine the criteria for judging the photoallergy potential, photo-ADRA with or without photoirradiation was performed using 60 photoallergenic chems., and cysteine and lysine derivatives were detected using high-performance liquid chromatog. either by absorbance or fluorescence measurement. The accuracy of prediction was 81.4% (48 of 59) and 80.0% (48 of 60) using the absorbance and fluorescence methods, resp. Furthermore, we prepared three types of pseudo-mixtures where we added one photoallergen along with five nonphotoallergens and performed the photo-ADRA by the UV and fluorescence methods. The result of the fluorescence method was almost the same as that obtained with the use of a single photoallergen and hence the outcome was not affected by the mixture Thus, this study not only showed a method of evaluating the photoallergy potential of a single chem. but also a mixture, making it useful as an in chemico photoallergy alternative test. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).SDS of cas: 85-91-6
The Article related to photoallergenic chem cysteine lysine derivative photoadra, adra, dpra, hplc-fl, hplc-uv, photoallergy, Biochemical Methods: Other (Not Covered At Other Subsections) and other aspects.SDS of cas: 85-91-6
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