On July 16, 2021, Xu, Yuan-Ze; Wen, Qi-Ling; Sha, Feng; Li, Qiong; Wu, Xin-Yan published an article.COA of Formula: C9H11NO2 The title of the article was Total synthesis of acronycine and noracronycine: An aryne amination approach. And the article contained the following:
Acronycine and noracronycine are chromene-containing alkaloids with significant biol. activity. We have accomplished a concise total synthesis of acronycine and noracronycine. The key step, regioselective nucleophilic addition of anthranilate to chromene-type arynes under mild and transition-metal-free conditions was achieved. In addition, further modifications of nucleophilic addition products, such as hydrogenation, O-functionalization and palladium-catalyzed coupling reactions have also been developed, providing a concise procedure for these alkaloids and their derivatives The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).COA of Formula: C9H11NO2
The Article related to acronycine synthesis regioselective nucleophilic addition, noracronycine synthesis, Alkaloids: Alkaloids Containing One Nitrogen Atom In A Ring and other aspects.COA of Formula: C9H11NO2
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