On May 31, 2022, Wang, Shengxuan; Liu, Tingjun; Sun, Lili; Du, Hongxia; Xu, Zhongjin; Li, Ranran; Yu, Ying; Mao, Yongjiang; Shi, Kerong published an article.Application of 2358-84-1 The title of the article was Menin regulates lipid deposition in mouse hepatocytes via interacting with transcription factor FoxO1. And the article contained the following:
Non-alc. fatty liver disease (NAFLD) is rapidly being recognized as the leading cause of chronic liver disease worldwide. Men1, encoding protein of menin, is a key causative gene of multiple endocrine neoplasia type 1 syndrome including pancreatic tumor. It is known that insulin that secretes by endocrine tissue pancreatic islets plays a critical role in hepatic metabolism Mouse model of hemizygous deletion of Men1 was shown to have severe hepatic metabolism disorders. However, the mol. function of menin on lipid deposition in hepatocytes needs to be further studied. Transcriptome sequencing does show that expression suppression of Men1 in mouse hepatocytes widely affect signaling pathways involved in hepatic metabolism, such as fatty acid metabolism, insulin response, glucose metabolism and inflammation. Further mol. studies indicates that menin overexpression inhibits expressions of the fat synthesis genes Srebp-1c, Fas, and Acc1, the fat differentiation genes Pparγ1 and Pparγ2, and the fat transport gene Cd36, thereby inhibiting the fat accumulation in hepatocytes. The biol. process of menin regulating hepatic lipid metabolism was accomplished by interacting with the transcription factor FoxO1, which is also found to be critical for lipid metabolism Moreover, menin responds to insulin in hepatocytes and mediates its regulatory effect on hepatic metabolism Our findings suggest that menin is a crucial mediation factor in regulating the hepatic fat deposition, suggesting it could be a potential important therapeutic target for NAFLD. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Application of 2358-84-1
The Article related to menin lipid deposition hepatocyte transcription factor, foxo1, hepatocyte, lipid metabolism, menin, non-alcoholic fatty liver disease (nafld), Mammalian Pathological Biochemistry: Digestive Tract Diseases and other aspects.Application of 2358-84-1
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