Sugimura, Takashi; Nakagawa, Satoshi; Kamata, Naoya; Tei, Takahiro; Tajiri, Takashi; Tsukiyama, Ryo-ichi; Okuyama, Tadashi; Okamoto, Yasuaki published an article in 2015, the title of the article was Ligand-acceleration by a chiral modifier in the enantioselective hydrogenation of methyl acetoacetate on a Raney nickel catalyst: effect of a modifier configuration.Quality Control of (R)-Methyl 3-hydroxybutanoate And the article contains the following content:
Reaction rate and enantioselectivity of asym. hydrogenation of Me acetoacetate were studied over Raneynickel catalysts modified with (R,R)-tartaric acid, malic acid, or succinic acid to reveal the impacts of the modifier configuration. Catalysts comodified with two different acids were also examined to confirm the conclusions. From anal. of the enantiomer ratio of the hydrogenation product and initial reaction rate, tartaric acid (TA) was found to have dual functions as the modifier during the hydrogenation; effective suppression of the racemic catalysis on bare Ni surface and extensive enantiodifferentiating ligand acceleration by adsorbed TA. It was demonstrated that each adsorbed chiral modifier mol. independently takes part in the enantiospecific hydrogenation. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Quality Control of (R)-Methyl 3-hydroxybutanoate
The Article related to methyl acetoacetate enantioselective hydrogenation raney nickel chiral ligand configuration, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.Quality Control of (R)-Methyl 3-hydroxybutanoate
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