Shimomura, Hiromi; Sanada, Kazuo published an article in 1980, the title of the article was Synthesis of DL-γ-carboxyglutamic acid.Computed Properties of 59524-07-1 And the article contains the following content:
DL-γ-Carboxyglutamic acid (I) was prepared from Z-DL-Ser(OTos)OBzl (II; Tos = 4-MeC6H4SO2) and Z-NH-C(=CH2)-CO2Bzl (III; Z = PhCH2O2C) through Z-NH-C[CH2(CO2Bzl)]2-CO2Bzl (IV). A reaction mixture of Z-DL-Ser-OBzl with Tos-Cl in absolute pyridine, was adsorbed on silica gel column and eluted with C6H6 to sep. 36% III and 34% II. II was added to a mixture of 50% NaH and CH2(CO2Bzl)2 in DMF under N2 to give 94% IV, which was also similarly prepared from III. IV in MeOH was hydrogenated in the presence of 10% Pd-C to give 62% I. I showed two peaks in amino acid anal., when it was eluted with buffer solutions of pH 1-3. The experimental process involved the reaction of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate(cas: 59524-07-1).Computed Properties of 59524-07-1
The Article related to carboxyglutamic acid, serinate aminoacrylate reaction, Synthesis of Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Computed Properties of 59524-07-1
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