Shim, Jae Ho; Hong, Yeonsun; Kim, Ji Hae; Kim, Hyeon Soo; Ha, Deok-Chan published an article in 2021, the title of the article was Organocatalytic Asymmetric Michael Addition in Aqueous Media by a Hydrogen-Bonding Catalyst and Application for Inhibitors of GABAB Receptor.Product Details of 10472-24-9 And the article contains the following content:
Catalysts based on (R, R)-1,2-diphenylethylenediamine are, as chiral organic catalysts, applied to the asym. Michael addition to α, β-unsaturated nitroalkenes under neutral conditions. The role of an aqueous medium for organic catalytic activity can be reversed concerning hydrophilic-hydrophobic function depending on the reaction conditions. In this study, to provide an environmentally friendly system, the thiourea-based catalyst substituted with 3,5-(CF3)2-Ph was used in water solvents. The hydrophobic effect of the substituent provided fast reaction, high chem. yield, and mirror-image selectivity. This reaction allowed the preparation of GABAB agonists in an optically pure manner. Addnl., GABA (γ-aminobutyric acid) analogs such as baclofen and phenibut were synthesized as R-type S-type with high optical purity. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Product Details of 10472-24-9
The Article related to organocatalytic asym michael addition hydrogen bonding catalyst gabab receptor, Pharmacology: Other (All Agents and Effects Not Otherwise Assignable) and other aspects.Product Details of 10472-24-9
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