Rudolph, Tobias; Espeel, Pieter; Du Prez, Filip E.; Schacher, Felix H. published an article in 2015, the title of the article was Poly(thiolactone) homo- and copolymers from maleimide thiolactone: synthesis and functionalization.Safety of 3-Aminodihydrothiophen-2(3H)-one hydrochloride And the article contains the following content:
We describe the synthesis of a thiolactone-functionalized maleimide (MITla), and its (co)polymerization into poly(thiolactone) homo- and copolymers via controlled or free radical polymerization (CRP or FRP) techniques. Homopolymers were synthesized using FRP whereas MITla was copolymerized with styrene and N-iso-propylacrylamide (NIPAAm) via RAFT. In that way, we were able to combine the properties of a maleimide with the possibility to use the thiolactone side chain functionality in subsequent double modification reactions. Thiolactones are susceptible to nucleophilic ring-opening in the presence of primary amines, releasing a thiol moiety that can be used for conjugate addition (nucleophilic thiol-ene) reactions afterwards. We synthesized and characterized copolymers of different compositions, followed by site-specific double modification reactions with a combination of n-butylamine and Me acrylate. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Safety of 3-Aminodihydrothiophen-2(3H)-one hydrochloride
The Article related to polythiolactone maleimide thiolactone polymerization, Chemistry of Synthetic High Polymers: Organic Addition Polymerization and other aspects.Safety of 3-Aminodihydrothiophen-2(3H)-one hydrochloride
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