Reith, Melissa A.; Kardas, Sinan; Mertens, Chiel; Fossepre, Mathieu; Surin, Mathieu; Steinkoenig, Jan; Du Prez, Filip E. published an article in 2021, the title of the article was Using nickel to fold discrete synthetic macromolecules into single-chain nanoparticles.Recommanded Product: 6038-19-3 And the article contains the following content:
Macromols. found in Nature display a precise control over the primary as well as higher ordered architectures. To mimic the folding found in Nature, we herein demonstrate the design and characterization of single-chain nanoparticles that are formed by the folding of sequence-defined macromols. with metal ions. The study showcases the influence of the loop size of such precision macromols. on their relative hydrodynamic radius. The sequence-defined structures are fabricated using thiolactone chem., where two picolyl moieties are installed forming a valuable ligand system for subsequent metal complexation. Next, metal ions such as Ni(II) and Cu(II) ions are introduced to fold the unimers into sequence-defined single-chain nanoparticles (SD-SCNPs). After proving the successful complexation using a trimer, a systematic study is conducted altering the distance between the resp. ligands by incorporating variable numbers of non-functionalized spacer units. Finally, the loop size formation of the SD-SCNPs is evidenced by DOSY measurements. The result indicates that the positioning of the ligands plays a crucial role on the compaction process and, more specifically, on the final size of the SD-SCNP. In addition, mol. dynamics simulations show the effects of the sequence and Ni(II) complexation on the structure and compaction of the SD-SCNPs, and highlight the differences of the nanoparticles’ shape when varying the number of spacer units. Finally, the system is further expanded to a dodecamer and even a heptadecamer with drastically decreased hydrodynamic radii after compaction. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Recommanded Product: 6038-19-3
The Article related to single chain nanoparticle macromol preparation property, Chemistry of Synthetic High Polymers: Organic Addition Polymerization and other aspects.Recommanded Product: 6038-19-3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics