On August 7, 2019, Muramatsu, Wataru; Hattori, Tomohiro; Yamamoto, Hisashi published an article.Electric Literature of 53838-27-0 The title of the article was Substrate-directed Lewis-acid catalysis for peptide synthesis. And the article contained the following:
A Lewis-acid-catalyzed method for the substrate-directed formation of peptide bonds has been developed, and this powerful approach is utilized for the new “remote” activation of carboxyl groups under solvent-free conditions. The presented method has the following advantages: (1) the high-yielding peptide synthesis uses a tantalum catalyst for any amino acids; (2) the reaction proceeds without any racemization; (3) the new substrate-directed chem. ligation using the titanium catalyst is applicable to convergent peptide synthesis. These advantages overcome some of the unresolved problems in classical peptide synthesis. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Electric Literature of 53838-27-0
The Article related to peptide synthesis substrate directed lewis acid catalysis tantalum racemization, substrate directed ligation titanium catalyst solvent free neutralization solubility, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Electric Literature of 53838-27-0
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