On July 18, 1980, Miller, Marvin J. published an article.COA of Formula: C18H17NO4 The title of the article was Isourea-mediated preparation of dehydro amino acids. And the article contained the following:
Z-NHCH(CHROH)CO2R1 (I; Z = PhCH2O2C; R = H, R1 = Me, CH2Ph; R, = Me, R1 = CH2Ph) were dehydrated by carbodiimides R2N:C:NR3 (R2 = R3 = CHMe2, cyclohexyl; R2 = cyclohexyl, R3 = 2-morpholinoethyl) in the presence of CuCl catalyst to give 65-96.5% Z-NHCH(:CHR)CO2R1. Ac-Cys-OCH2Ph was treated with Me2CHN:C:NCHMe2 in the presence of CuCl to give AcNHC(:CH2)CO2CH2Ph, whereas this reaction in the absence of CuCl gave [AcNHCH(CO2CH2Ph)CH2]2S. I were prepared by treating Z-NHCH(CHROH)CO2H with O-alkylisourea derivatives The experimental process involved the reaction of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate(cas: 59524-07-1).COA of Formula: C18H17NO4
The Article related to dehydro amino acid, hydroxy amino acid dehydration carbodiimide, isourea reaction amino acid, Synthesis of Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.COA of Formula: C18H17NO4
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