McInnis, Christine E.; Blackwell, Helen E. published an article in 2011, the title of the article was Thiolactone modulators of quorum sensing revealed through library design and screening.Name: 3-Aminodihydrothiophen-2(3H)-one hydrochloride And the article contains the following content:
Quorum sensing (QS) is a process by which bacteria use small mols. or peptidic signals to assess their local population densities. At sufficiently high d., bacteria can alter gene expression levels to regulate group behaviors involved in a range of important and diverse phenotypes, including virulence factor production, biofilm formation, root nodulation, and bioluminescence. Gram-neg. bacteria most commonly use N-acylated L-homoserine lactones (AHLs) as their QS signals. The AHL lactone ring is hydrolyzed relatively rapidly at biol. pH, and the ring-opened product is QS inactive. The authors sought to identify AHL analogs with heightened hydrolytic stability, and thereby potentially heightened activity, for use as non-native modulators of bacterial QS. As part of this effort, they probed the utility of thiolactone analogs in the current study as QS agonists and antagonists in Gram-neg. bacteria. A focused library of thiolactone analogs was designed and rapidly synthesized in solution The authors examined the activity of the library as agonists and antagonists of LuxR-type QS receptors in Pseudomonas aeruginosa (LasR), Vibrio fischeri (LuxR), and Agrobacterium tumefaciens (TraR) using bacterial reporter strains. The thiolactone library contained several highly active compounds, including some of the most active LuxR inhibitors and the most active synthetic TraR agonist reported to date. Anal. of a representative thiolactone analog revealed that its hydrolysis half-life was almost double that of its parent AHL in bacterial growth medium. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Name: 3-Aminodihydrothiophen-2(3H)-one hydrochloride
The Article related to thiolactone bacteria quorum sensing, Microbial, Algal, and Fungal Biochemistry: Antimicrobial Sensitivity and other aspects.Name: 3-Aminodihydrothiophen-2(3H)-one hydrochloride
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