Masumoto, Eiichi; Nagabuchi, Hayate; Kashige, Nobuhiro; Okabe-Nakahara, Fumi; Miake, Fumio; Yamagata, Kenji; Maruoka, Hiroshi published an article in 2019, the title of the article was Synthesis and DNA cleavage activity of novel spiro-[cyclobutathiazole-4,4′-pyrazole] derivatives.Product Details of 707-07-3 And the article contains the following content:
A facile and efficient synthesis of novel spiro pyrazole derivatives containing cyclobutathiazole moiety was described. The key substrate pyrazole-thiazolidine derivative as the building block for bis-heterocycles was formed via a Knoevenagel-type condensation of thiazolidinedione with pyrazol-3-one. Thermal treatment of the pyrazole-thiazolidine derivative with orthoesters in refluxing toluene caused an C-attack nucleophilic substitution, followed by an intramol. cyclization/elimination sequence, giving the corresponding spiro[cyclobutathiazole-4,4′-pyrazole] derivatives All the synthesized compounds were characterized by spectroscopic anal. and were tested for their DNA cleavage activity in-vitro. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Product Details of 707-07-3
The Article related to pyrazolylidene thiazolidinone preparation dna cleavage activity, spiro cyclobutathiazole pyrazole preparation dna cleavage activity, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Product Details of 707-07-3
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