On June 28, 2018, Liu, Phillip C.; Volgina, Alla; Wynn, Richard; Zolotarjova, Nina; Wu, Liangxing; Xiao, Kaijiong; Mei, Song; Lu, Liang; Zhu, Wenyu; Ye, Yingda; Wang, Haisheng; Qian, Ding-Quan; Yao, Wenqing published a patent.Computed Properties of 37480-41-4 The title of the patent was Synthesis of tetrahydroimidazo[4,5-c]pyridine derivatives as PD-L1 internalization inducers. And the patent contained the following:
Compositions of tetrahydroimidazo[4,5-c]pyridine derivatives I [Z = 5 to 14-membered heteroaryl, 4 to 14-membered heterocycloalkyl, C6-10 aryl, C3-10 cycloalkyl,m etc., L = bond, NH, O, C(O)NH, C(:NOH)NH, etc., R21, R22 = halo, C1-6 alkyl, CN, R23 = H, C1-6 alkyl, C1-6 haloalkyl, X = (R25)n, R25 = C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, etc., Y = (R26)m, R26 = C1-4 alkyl, CN, halo, OH, CO2H, etc., Z = (R27)p, R27 = H, halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, etc., n = 0-3, m = 0-3, p = 1-6, dotted bond = single or double bond to maintain the 5-membered imidazole ring aromaticity] and methods for inducing PD-L1 internalization are disclosed. The methods include reducing the amount of cell surface PD-L1 by contacting a cell expressing PD-L1 with a compound that binds to the cell surface PD-L1 and induces PD-L1 internalization. Compounds that induce PD-L1 internalization can be used to enhance, stimulate and/or increase an immune response and treat a PD-1-related disease or condition. The experimental process involved the reaction of Methyl 1-methyl-4-oxocyclohexanecarboxylate(cas: 37480-41-4).Computed Properties of 37480-41-4
The Article related to imidazopyridine preparation pd l1 internalization antitumor immunomodulator, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Computed Properties of 37480-41-4
Referemce:
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