On July 1, 2019, Liao, Jun; Pan, Bo; Liao, Guochao; Zhao, Qingjie; Gao, Yun; Chai, Xiaoyun; Zhuo, Xiaobin; Wu, Qiuye; Jiao, Binghua; Pan, Weihua; Guo, Zhongwu published an article.SDS of cas: 79642-50-5 The title of the article was Synthesis and immunological studies of β-1,2-mannan-peptide conjugates as antifungal vaccines. And the article contained the following:
Fungal cell surface carbohydrates and proteins are useful antigens for the development of antifungal vaccines. In this study, glycopeptides consisting of the β-1,2-mannan and N-terminal peptide epitopes of Candida albicans (C. albicans) cell wall phosphomannan complex and Als1p (rAls1p-N) protein, resp., were synthesized and covalently conjugated with keyhole limpet hemocyanin (KLH) and human serum albumin (HSA) through homobifunctional disuccinimidyl glutarate. The resultant KLH-conjugates were immunol. evaluated using Balb/c mice to reveal that they induced high levels of IgG antibodies. Furthermore, these conjugates showed self-adjuvanting property, as they could promote robust antibody responses without the presence of an external adjuvant. More significantly, the obtained antisera could effectively recognize both the carbohydrate and the Als1 peptide epitopes and immunofluorescence and flow cytometry assays also demonstrated that the elicited antibodies could react with the cell surface of a number of fungi, including C. albicans, C. tropicalis, C. lusitaniae and C. glabrata. These results suggested the great potential of these conjugates as antifungal vaccines. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).SDS of cas: 79642-50-5
The Article related to fungus candida oligosaccharide als1 peptide glycopeptide glycoconjugate antifungal vaccine, candida albicans, fungus, glycoconjugate, glycopeptide, vaccine, β-1,2-mannan, Immunochemistry: Adjuvants, Antigens, Haptens, and Vaccines and other aspects.SDS of cas: 79642-50-5
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