On November 1, 2019, Li, Qingjiang; Jiang, Wenjie; Guo, Jiatong; Jaiswal, Mohit; Guo, Zhongwu published an article.Formula: C13H14N2O8 The title of the article was Synthesis of Lewis Y Analogues and Their Protein Conjugates for Structure-Immunogenicity Relationship Studies of Lewis Y Antigen. And the article contained the following:
Analogs of cancer-associated Lewis Y (Ley) antigen with varying structures at the reducing end were synthesized by a highly efficient strategy involving one-pot preactivation-based iterative glycosylation to obtain the key tetra-/pentasaccharide intermediates, which was followed by stereoselective fucosylation. After global deprotection, these oligosaccharides were coupled with carrier protein keyhole limpet hemocyanin. The resultant glycan-protein conjugates were subjected to immunol. studies in mice. It was disclosed that the conjugate of the pentasaccharide analog of Lewis Y antigen was more immunogenic than that of the hexasaccharide analog, but the antisera of both conjugates could indiscriminately recognize each carbohydrate hapten. These results suggested that the short Lewis Y analog may be utilized to develop functional conjugate cancer vaccines. More importantly, the results also proved that the reducing-end glucose residue in the hexasaccharide analog of Lewis Y was probably not involved in its interaction with the immune system, whose discovery can have a broad impact on the design of new cancer vaccines. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Formula: C13H14N2O8
The Article related to lewis y analog protein conjugate structure immunity relationship, Immunochemistry: Adjuvants, Antigens, Haptens, and Vaccines and other aspects.Formula: C13H14N2O8
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