On December 10, 2015, Kumaravel, Gnanasambandam; Peng, Hairuo; Xin, Zhili published a patent.Application In Synthesis of Methyl 1-methyl-4-oxocyclohexanecarboxylate The title of the patent was Preparation of dihydropyrazolopyridine derivatives for use as ATX modulators. And the patent contained the following:
Title compounds I [A = (un)substituted Ph, cyclohexyl, or heteroaryl; X = C(O), C(O)2, C(O)NH, or C(O)N(alkyl); Z = bond or alkylenyl; R2 = H, halo, CN, (un)substituted alkyl; R3 = CH3, CH3OCH3, (un)substituted carbocyclyl, etc.], and their pharmaceutically acceptable salts, are prepared and disclosed as ATX modulators. Thus, e.g., II was prepared by a multistep procedure (preparation given). I were evaluated in ATX activity assays, e.g., II demonstrated an IC50 value of no greater than 100 nM. The experimental process involved the reaction of Methyl 1-methyl-4-oxocyclohexanecarboxylate(cas: 37480-41-4).Application In Synthesis of Methyl 1-methyl-4-oxocyclohexanecarboxylate
The Article related to dihydropyrazolopyridine preparation atx modulator, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application In Synthesis of Methyl 1-methyl-4-oxocyclohexanecarboxylate
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