On December 31, 2006, Kondratenko, R. M.; Baltina, L. A. Jr.; Baltina, L. A.; Baschenko, N. Zh.; Tolstikov, G. A. published an article.Product Details of 53838-27-0 The title of the article was Synthesis and immunomodulating activity of new glycopeptides of glycyrrhizic acid containing residues of L-glutamic acid. And the article contained the following:
New glycopeptides of glycyrrhizic acid [i.e., GA; (3β,20β)-20-carboxy-11-oxo-30-norolean-12-en-3-yl-2-O-β-D-glucopyranuronosyl-α-D-glucopyranosiduronic acid], containing Glu residues and their α-Me esters, γ-Me esters, and α,γ-di-Me esters were synthesized using N,N’-dicyclohexylcarbodiimide in the presence of N-hydroxybenzotriazole or N-hydroxysuccinimide. Formation of amide bonds was observed on all the three COOH groups of GA, or selectively on the COOH groups of the GA carbohydrate part in dependence on the ratio of reagents and the reaction conditions. The GA glycopeptide with three residues of Glu(OH)-OMe at a dose of 2 mg/kg stimulated the production of antibody-forming cells in mouse spleen in comparison with the control. The GA glycopeptide containing Glu residues only in the GA carbohydrate part turned out to be an immunosuppressor. The glycopeptide of the 30-Me ester of GA with residues of free Glu in its carbohydrate part increased the hemagglutinin titer at oral doses of 2 and 10 mg/kg. All the studied compounds had practically no effect on the delayed-type hypersensitivity in mice. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Product Details of 53838-27-0
The Article related to immunomodulating activity glycopeptide glycyrrhizic glutamic acid preparation, licorice glycyrrhiza glabra glycopeptide glutamate preparation immunomodulator, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Product Details of 53838-27-0
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