On October 9, 2008, Kaila, Neelu; Janz, Kristin Marie; Huang, Adrian; Moretto, Allessandro Fabio; Bedard, Patricia Ward published a patent.COA of Formula: C12H14F3NO2 The title of the patent was Preparation of quinoline compounds as selectin inhibitors for disease treatment. And the patent contained the following:
The present teachings relate to novel compounds of formula I wherein R1 is -OR9, -C(O)R10, etc.; R2 is -C(O)OR9, etc.; R3 and R3′ independently are H, -CN, -NO2, halo, etc.; R4-R7 independently are H, C1-10alkyl, etc.; or R3 and R3′ together, R4 and R5 together, and R6 and R7 together form part of a ring; R8 is (un)substituted C6-14 aryl or 5-14 membered heteroaryl; R9 is H, -C(O)R10, etc.; R10 is H, OH, SH, etc. Compounds of the present teachings can act as antagonists of the mammalian adhesion proteins known as selectins. Methods for treating or preventing selectin-mediated disorders are provided, which include administration of these compounds in a therapeutically effective amount Synthetic procedures for preparing I are exemplified. Example compound II, prepared by reacting the appropriate indoline-2,3-dione with the appropriate 2-oxopropyl acetate, caused 37% inhibition in a Biacore P-selectin/PSGL-1 inhibition assay at 250μM. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).COA of Formula: C12H14F3NO2
The Article related to quinoline compound preparation selectin inhibitor disease treatment, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.COA of Formula: C12H14F3NO2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics