On July 3, 2003, Hewawasam, Piyasena; Fan, Wenhong; Ding, Min; Flint, Kim; Cook, Deborah; Goggins, Gregory D.; Myers, Robert A.; Gribkoff, Valentin K.; Boissard, Christopher G.; Dworetzky, Steven I.; Starrett, John E. Jr.; Lodge, Nicholas J. published an article.Safety of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the article was 4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: Novel Maxi-K Channel Opening Relaxants of Corporal Smooth Muscle Targeted for Erectile Dysfunction. And the article contained the following:
Novel 4-aryl-3-(hydroxyalkyl)quinoline-2-ones I [R1 = HO, MeO; R2 = HO(CH2)n, n = 1 – 3; R2 = (E)-HOCH2CH:CH] were prepared and evaluated as openers of the cloned maxi-K channel hSlo expressed in Xenopus laevis oocytes by utilizing electrophysiol. methods. The effect of these maxi-K openers on corporal smooth muscle was studied in vitro using isolated rabbit corpus cavernosum. A potent maxi-K opener was identified as an effective relaxant of rabbit corporal smooth muscle and shown to be active in an in vivo animal model of male erectile function. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Safety of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate
The Article related to quinolinone hydroxyalkyl preparation corporal smooth muscle relaxant erectile disfunction, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Safety of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate
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