On May 31, 2002, Gutheil, William G.; Xu, Qingchai published an article.HPLC of Formula: 53838-27-0 The title of the article was N-to-C solid-phase peptide and peptide trifluoromethylketone synthesis using amino acid tert-butyl esters. And the article contained the following:
Solid-phase peptide synthesis in the N-to-C direction, opposite to the classical C-to-N direction of peptide, synthesis, provides the synthetically versatile C-terminal carboxyl group for further modification into C-terminally modified peptide mimetics. These are of general interest as potential bioactive agents, particularly as protease inhibitors. Elaboration of peptide mimetics on the solid-phase would facilitate synthesis of peptide mimetic combinatorial libraries. This report describes an effective strategy for solid-phase inverse peptide synthesis based on readily available amino acid tert-Bu esters. The potential of this approach for peptide mimetic synthesis is demonstrated by the solid-phase synthesis of two peptide trifluoromethylketones. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).HPLC of Formula: 53838-27-0
The Article related to solid phase inverse peptide synthesis amino acid butyl ester, peptidomimetic peptide trifluoromethylketone solid phase inverse synthesis, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.HPLC of Formula: 53838-27-0
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics