On March 17, 2017, Gerasimaite, Ruta; Pavlovic, Igor; Capolicchio, Samanta; Hofer, Alexandre; Schmidt, Andrea; Jessen, Henning J.; Mayer, Andreas published an article.COA of Formula: C10H14O3 The title of the article was Inositol pyophosphate specificity of the SPX-dependent polyphosphate polymerase VTC. And the article contained the following:
The free energy of nucleotide hydrolysis depends on phosphate concentration Cells regulate cytosolic phosphate levels by orchestrating phosphate acquisition and storage through inositol pyrophosphates (PP-InsP) and SPX domains. Here, we report the synthesis of novel 5-PPP-InsP5 containing a triphosphate subunit. Using this and a series of synthetic PP-InsP, we examined the ligand specificity of the SPX domain in the PP-InsP-controlled yeast polyphosphate polymerase VTC. SPX decodes the relative positioning of the phosphoric anhydrides, their structure (diphosphate vs. triphosphate), and the presence of other phosphates on the inositol ring. Despite the higher potency of 1,5-(PP)2-InsP4, 5-PP-InsP5 was the primary activator of VTC in cells, indicating that its higher concentration compensated for its lower potency. 1,5-(PP)2-InsP4 levels rose and could become relevant under stress conditions. Thus, SPX domains may integrate PP-InsP-dependent signaling to adapt cytosolic phosphate concentrations to different metabolic situations. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).COA of Formula: C10H14O3
The Article related to spx domain dependent polyphosphate polymerase vtc inositol pyophosphate specificity, Enzymes: Substrates-Cofactors-Inhibitors-Activators-Coenzymes-Products and other aspects.COA of Formula: C10H14O3
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