On March 26, 2009, Gellerman, Gary published a patent.SDS of cas: 53838-27-0 The title of the patent was Preparation of diketopiperazines and related heterocyclic scaffolds which are useful for the preparation of combinatorial libraries. And the patent contained the following:
The invention discloses heterocyclic scaffolds I [X, Y, Z are independently CH2 or CO; R1, R2 are (CH2)0-5CO2H or (CH2)0-5-Q1-P1 or (CH2)0-5-Q2-P2, resp.; R3 is (CO)0-1-A-CO2H or (CO)0-1-A-Q3-P3, where Q1, Q2, Q3 are linkers N, NH, O, or S; P1, P2, P3 are protecting groups; A is a linker (CH2)0-5, O(CH2)0-5, NH(CH2)0-5, -N-alkyl-(CH2)0-5, phenylene-(CH2)0-5, cyclopropylene-(CH2)0-5, cyclobutylene-(CH2)0-5, cyclopentylene-(CH2)0-5, cyclohexylene-(CH2)0-5, piperidinylene-(CH2)0-5, pyrrolene-(CH2)0-5; R4 is H or CH2 or CO attached to linker A], which are useful, for example, for the solid-phase organic synthesis of combinatorial libraries. Thus, I (X, Y are CO; Z-A-R3 is CH2CO2H; R1-CH2 is ornithine Alloc-protected side chain; R2-CH2 is lysine Fmoc-protected side chain; R4 is H) was prepared via peptide coupling in solution and heterocyclization (NMM in 2-butanol at reflux for 10 h). The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).SDS of cas: 53838-27-0
The Article related to peptide piperazinedione preparation scaffold combinatorial library, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.SDS of cas: 53838-27-0
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics