On October 26, 2021, Duan, Wenhu; Shen, Xu; Wang, Wei; Wang, Jiaying; Cao, Sufen; Lv, Jianlu; Xu, Xu published a patent.Application In Synthesis of Methyl 2-(3-formylphenyl)acetate The title of the patent was Preparation of compounds with AMPK agonistic activity and prodrugs thereof and their application in medicine. And the patent contained the following:
The invention discloses the preparation method of the compounds with AMPK agonistic activity with general formula I, [wherein X = H or halogen; M = N or CH, R1 = substituted or unsubstituted 6-10 membered aryl, substituted or unsubstituted 3-10 membered heteroaryl containing 1-3 heteroatoms selected from N, O and S; R2 = hydroxyl, carboxyl, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted 6-10 membered aryl and substituted or unsubstituted 3-10 membered heteroaryl containing 1-3 heteroatoms selected from N, O and S], which has the advantages of preparing and treating diseases related to abnormal energy metabolism, neurodegenerative diseases and inflammation related diseases; cardiovascular and cerebrovascular diseases, tumor drug. For example, 2-(3-(7-chloro-6-(4-(1- hydroxycyclobutyl) phenyl)-2-oxo-1,2- dihydroquinoline-3-yl) phenyl) acetic acid was prepared via Suzuki-coupling with 1-(4- bromophenyl) cyclobutanol and bis(pinacolato)diboron, hydrolysis of di-Et isophthalate, followed by acylation with 2-amino-5-bromo-4-chlorobenzaldehyde, followed by Knoevenagel reaction, followed by Suzuki coupling with 1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl] cyclobutanol, and followed by hydrolysis. The compounds with AMPK agonistic activity can be used as therapeutic agents for diseases related to abnormal energy metabolism, neurodegenerative diseases, neurol. and mitochondrial dysfunction and disorder diseases, inflammation related diseases, cardiovascular and cerebrovascular diseases and tumors. The experimental process involved the reaction of Methyl 2-(3-formylphenyl)acetate(cas: 142327-44-4).Application In Synthesis of Methyl 2-(3-formylphenyl)acetate
The Article related to ampk agonist quinoline condensation suzuki coupling hydrolysis human, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Application In Synthesis of Methyl 2-(3-formylphenyl)acetate
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