On September 30, 1994, Crossley, Maxwell J.; Stamford, Andrew W. published an article.Recommanded Product: Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate The title of the article was Studies directed towards the total synthesis of anticapsin and related compounds. II. Diels-Alder addition of N-acyl dehydroalanine esters to 1-trimethylsilyloxycyclohexa-1,3-diene. And the article contained the following:
In a study directed towards the total synthesis of anticapsin I and related compounds, the Diels-Alder addition of N-acyl dehydroalanine esters CH2:C(NHR1)CO2R2 [II; R1 = benzyloxycarbonyl (Cbz), Boc, CF3CO, R2 = benzyl (Bzl); R1 = Ac, R2 = Me] and dehydropeptide III to cyclohexa-1,3-diene IV was investigated. The cycloadditions were highly regioselective; the Diels-Alder reaction of II with IV gave bicyclo[2.2.2]oct-5-ene-2-carboxylate derivatives V and VI in moderate to good yields, whereas the Diels-Alder reaction of III with IV gave cycloadducts VII, VIII, IX and X. A modest stereoselectivity was observed in the reactions, with the endo-adducts favored over the exo-adducts by a ratio of 1.5-3.3:1. Adducts V (R1 = Cbz, Boc; R2 = Bzl) and underwent stereoselective epoxidation to the less hindered face of the olefinic double bond. Reaction of the resultant epoxides with TiCl4 afforded carbolactones, thereby allowing the assignment of endo stereochem. to adducts V (R1 = Cbz, Boc; R2 = Bzl). The stereochem. of the remaining adducts was assigned by the use of 1H NMR spectroscopy. The experimental process involved the reaction of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate(cas: 59524-07-1).Recommanded Product: Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate
The Article related to diels alder cycloaddition acyl dehydroalanine cyclohexadiene, anticapsin total synthesis, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Recommanded Product: Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics