Chong, Zhen Yee; Sandanamsamy, Sylvia; Ismail, Nur Najihah; Mohamad, Suriyati; Hanafiah, Khayriyyah Mohd published an article in 2021, the title of the article was Bio-Guided fractionation of oil palm (Elaeis guineensis) fruit and interactions of compounds with first-line antituberculosis drugs against Mycobacterium tuberculosis H37Ra.SDS of cas: 3319-31-1 And the article contains the following content:
Natural products with antimycobacterial adjuvant potential may be utilized to address the rise of multidrug-resistant tuberculosis (TB). The antioxidant-rich oil palm (Elaeis guineensis) fruit (OPF) was investigated for antimycobacterial activity against Mycobacterium tuberculosis (MTB) H37Ra using bio-guided fractionation techniques, followed by determination of fractional inhibition index (FIC) with first-line anti-TB drugs. In vitro screening using microplate Alamar blue assay showed n-hexane and chloroform partitions of OPF mesocarp had a min. inhibitory concentration (MIC) of 400-800μg/mL. The n-hexane fraction contained nonanoic acid (C9H18O2), decanoic acid (C10H20O2), and dodecanoic acid (C12H24O2), identified by gas chromatog.-mass spectrometry, which all had an MIC of 50μg/mL. Nonanoic and decanoic acids had additive effects when combined with streptomycin (FIC index: 0.625) and rifampicin (FIC index: 0.75), resp. Isoniazid had a 16-fold increase in activity when combined with nonanoic acid and decanoic acid. The combination of nonanoic acid with streptomycin was bactericidal to 99.9% of MTB H37Ra by Day 7 of the time-kill assay, with structural damage of the cell wall observed using electron microscopy. Cytotoxicity assessment using Vero cells confirmed nonanoic acid had low toxicity with LC50 of > 200μg/mL. The bio-guided fractionation of OPF shows the presence of fatty acids with anti-TB adjuvant potential. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).SDS of cas: 3319-31-1
The Article related to elaeis fruit decanoic dodecanoic acid antituberculosis cytotoxicity tuberculosis, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.SDS of cas: 3319-31-1
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