On January 16, 2014, Bentley, Jonathan Mark; Brookings, Daniel Christopher; Brown, Julien Alistair; Cain, Thomas Paul; Chovatia, Praful Tulshi; Foley, Anne Marie; Gallimore, Ellen Olivia; Gleave, Laura Jane; Heifetz, Alexander; Horsley, Helen Tracey; Hutchings, Martin Clive; Jackson, Victoria Elizabeth; Johnson, James Andrew; Johnstone, Craig; Kroeplien, Boris; Lecomte, Fabien Claude; Leigh, Deborah; Lowe, Martin Alexander; Madden, James; Porter, John Robert; Quincey, Joanna Rachel; Reed, Laura Claire; Reuberson, James Thomas; Richardson, Anthony John; Richardson, Sarah Emily; Selby, Matthew Duncan; Shaw, Michael Alan; Zhu, Zhaoning published a patent.Synthetic Route of 37480-41-4 The title of the patent was Imidazopyridine derivatives as modulators of TNF activity and their preparation. And the patent contained the following:
A series of imidazo[1,2-a]pyridine derivatives of formula I, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments. Compounds of formula I wherein E is a bond, O, S, SO, SO2, etc.; Q is a bond, O, S, SO, SO2, NH and derivatives, etc.; Y is (un)substituted C3-7 cycloalkyl, (un)substituted aryl, (un)substituted heteroaryl, and (un)substituted C3-7 heterocyclyl; Z is H, halo, CF3, (un)substituted C1-6 alkyl, etc.; R1, R2, R3 and R4 are independently H, halo, CN, NO2, OH, etc.; and N-oxides, pharmaceutically acceptable salts, solvates, glucuronide derivatives and co-crystals thereof, are claimed. Example compound II was prepared by cyclocondensation of 5-(6-methoxypyridin-3-yl)pyridin-2-amine with acetaldehyde and 1,4-dichloro-2-isocyanobenzene. The invention compounds were evaluated for their TNFα modulatory activity. From the assay, it was determined that the tested example compounds all exhibited IC50 values of 50 μM or better. The experimental process involved the reaction of Methyl 1-methyl-4-oxocyclohexanecarboxylate(cas: 37480-41-4).Synthetic Route of 37480-41-4
The Article related to imidazopyridine preparation tnf modulator, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Synthetic Route of 37480-41-4
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