Bekkar, Nour El Houda; Meddah, Boumediene; Keskin, Bahadir; Sonnet, Pascal published an article in 2021, the title of the article was Oral acute toxicity, influence on the gastrointestinal microbiota and in vivo anti-salmonellosis effect of Zizyphus lotus (L.) and Ruta chalepensis (L.) essential oils.Product Details of 85-91-6 And the article contains the following content:
The aim of this study was to evaluate the chem. composition of Zizyphus lotus and Ruta chalepensis essential oils (EOs), the oral acute toxicity, influence on the gastrointestinal microbiota and the in vivo anti-salmonellosis effect. The EOs were isolated using the steam distillation process, and bioactive components were identified by gas chromatog.-mass spectrometry (GC-MS) anal. Oral acute toxicity, influence on the gastrointestinal flora composition and the anti-salmonellosis effect were elucidated using in vivo methods on exptl. animals. The GC-MS allowed us to identify 33 and 58 components in Z. lotus and R. chalepensis, resp. Di-isooctyl phthalate (89.857%) was found to be the major compound identified in Z. lotus. The main compounds in R. chalepensis were 2-undecanone (26.528%) followed by 2-nonanone (13.404%). The LD50 of EOs was found to be greater than 5000 mg/kg. Also, no neg. influence to intestinal microbiota was detected. An important decrease in S. enterica ssp arizonae cells achieving a bactericidal effect was recorded in rats treated with the EOs of both plants at a dose of 400 mg/kg. In parallel, an important significant (P < 0.05) increase in lymphocytes number was observed for all tested animals. A decrease in alk. phosphatase (ALP), amino alanine transferase (ALT) and aspartate aminotransferase (AST) levels was observed Furthermore, a reduced blood erythrocyte sedimentation rate (ESR) was recorded in treated animals. The Z. lotus and R. chalepensis act effectively as anti-salmonellosis agents, which support the use of these plants to cure gastrointestinal infections. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Product Details of 85-91-6
The Article related to zizyphus ruta essential oils gastrointestinal microbiota antisalmonellosis oral acute, Microbial, Algal, and Fungal Biochemistry: Composition and Products and other aspects.Product Details of 85-91-6
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