Bazhin, Denis N.; Kudyakova, Yulia S.; Roeschenthaler, Gerd-Volker; Burgart, Yanina V.; Slepukhin, Pavel A.; Isenov, Maksim L.; Saloutin, Victor I.; Charushin, Valery N. published an article in 2015, the title of the article was A Convenient Approach to CF3-Containing N-Heterocycles Based on 2-Methoxy-2-methyl-5-(trifluoromethyl)furan-3(2H)-one.Electric Literature of 707-07-3 And the article contains the following content:
New synthetic routes to trifluoromethylated N-heterocycles based on condensations of 2-methoxy-2-methyl-5-(trifluoromethyl)furan-3(2H)-one with bifunctional N-nucleophiles were described. For the first time, trifluoromethyl-containing pyrazoles, pyrazolines and isoxazolines bearing hydrazone or oxime groups could be obtained by a one-pot strategy based on reactions of 5-(trifluoromethyl)furan-3(2H)-one with two equivalent of the corresponding hydrazines or hydroxylamine in the presence of an acid. The interaction of furan-3(2H)-one with ureas proceeded under mild conditions to furnish 1H-furo[2,3-d]imidazol-2(3H)-one derivatives in good yield. Further, a trifluoromethyl-containing quinoxaline derivative was obtained by condensation of furan-3(2H)-one with ortho-phenylenediamine. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Electric Literature of 707-07-3
The Article related to methoxy methyltrifluoromethylfuranone nitrogen binucleophile, trifluoromethyl nitrogen heterocyclic preparation regioselective, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Electric Literature of 707-07-3
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