On June 19, 1997, Barth, Francis; Casellas, Pierre; Millan, Joseph; Oustric, Didier; Rinaldi, Murielle; Sarran, Martine published a patent.Formula: C10H11FO2 The title of the patent was 3-pyrazolecarboxamide derivatives having cannabinoid receptor affinity. And the patent contained the following:
Pyrazolecarboxamides I [R = amino, cycloalkoxy; R1 = H, (un)substituted alkyl; R2, R3 = (un)substituted Ph; R4, R5 = H, alkyl, CF3] were prepared as CB2 receptor antagonists (no data). Thus, 4-MeC6H4Ac was treated with di-Et oxalate and cyclized with N2H4, followed by alkylation with 3,4-Cl2C6H3CH2Br to give I [R = OH, R1, R4, R5 = H, R2 = 4-MeC6H4, R3 = 3,4-Cl2C6H3] which was amidated with (1S)-2-endo-amino-1,3,3-trimethylbicyclo[2.2.1]heptane (R6NH2), prepared from (1S)-(+)-fenchone, to give I [R = NHR6, R1, R4, R5 = H, R2 = 4-MeC6H4, R3 = 3,4-Cl2C6H3]. The experimental process involved the reaction of Ethyl 3-fluoro-4-methylbenzoate(cas: 86239-00-1).Formula: C10H11FO2
The Article related to pyrazolecarboxamide preparation cannabinoid antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Formula: C10H11FO2
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