On October 10, 2013, Ahn, Kay; Boehm, Markus; Cabral, Shawn; Carpino, Philip A.; Futatsugi, Kentaro; Hepworth, David; Kung, Daniel W.; Orr, Suvi; Wang, Jian published a patent.Electric Literature of 142327-44-4 The title of the patent was Preparation of pyrrolidinylimidazopyridinylpiperidinylmethanone derivatives and analogs for use as diacylglycerol acyltransferase 2 inhibitors. And the patent contained the following:
Title compounds I [A = CH2, O, S, etc.; B = bond, CH2, oxetanyl, (un)substituted cyclopropyl, etc.; C and D independently = N, CH, CF, or C(CH3), wherein only one is N; R1 = (un)substituted C(O)heterocyclyl, C(O)NH2, or heteroaryl; R2 = (un)substituted alkyl, alkoxy, cycloalkyl, aryl, etc.; R3 = OH, F, (un)substituted alkyl, or cycloalkyl; n = 0 to 2], and their pharmaceutically acceptable salts, are prepared and disclosed as diacylglycerol acyltransferase 2 (DGAT2) inhibitors. Thus, e.g., II was prepared by a multistep procedure (preparation given). Select I were evaluated in DGAT2 inhibition assays, e.g., II demonstrated an IC50 value of 1.7 nM. The experimental process involved the reaction of Methyl 2-(3-formylphenyl)acetate(cas: 142327-44-4).Electric Literature of 142327-44-4
The Article related to imidazopyridinylpiperidinylmethanone pyrrolidinyl derivative preparation diacylglycerol acyltransferase dgat2 inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Electric Literature of 142327-44-4
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