On May 6, 2010, Sugita, Kazuyuki; Otsuka, Masaki; Oki, Hitoshi; Haginoya, Noriyasu; Ichikawa, Masanori; Ota, Masahiro; Shibata, Norihiro published a patent.Formula: C12H14F3NO2 The title of the patent was Preparation of tricyclic heteroaryl compounds as squalene synthase inhibitors. And the patent contained the following:
Title compounds, e.g., I [or pharmaceutically acceptable salts or solvates thereof], etc., were prepared For example, reaction of compound II (preparation given) with NH2NH2·H2O followed by in-situ treatment with trifluoroacetic anhydride, de-allylation, ethylation, and hydrolysis afforded compound I. In squalene synthase inhibition assays, the IC50 of I was 0.98 nM. The invention compounds are claimed useful for the treatment of hypercholesterolemia, hyperlipidemia, etc. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Formula: C12H14F3NO2
The Article related to tricyclic heteroaryl preparation squalene synthase inhibitor, hypercholesterolemia hyperlipidemia treatment tricyclic heteroaryl preparation squalene synthase inhibition, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Formula: C12H14F3NO2
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