On February 24, 2022, Su, Wei-Guo; Zhang, Weihan; Deng, Wei; Yang, Haibin published a patent.Formula: C9H8F2O2 The title of the patent was Preparation of pyrimidinone compounds as RIPK1 kinase inhibitors and uses thereof. And the patent contained the following:
The invention relates to pyrimidinone compounds of formula I and their preparation and use RIPK1 kinase inhibitors. Compounds of formula I wherein R1 is H, C1-6 alkyl, C1-6 haloalkyl, etc.; R2 is H, halo, CN, etc.; Z is O, NR3 and CR4R5; R3 is H and C1-6 alkyl; R4 and R5 are each independently H, halo, CN, etc.; ring A is (un)substituted Ph and 5- to 6-membered heteroaryl; ring B is (un)substituted 5- to 12-membered heteroaryl, p is 0 and 1; and their pharmaceutically acceptable salts, solvates, racemic mixtures, enantiomers, diastereomers and tautomers, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their RIPK1 kinase inhibitor activity (data given). The experimental process involved the reaction of Methyl 2-(2,6-difluorophenyl)acetate(cas: 872046-08-7).Formula: C9H8F2O2
The Article related to pyrimidinone preparation ripk1 kinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Formula: C9H8F2O2
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