Dowgiallo, Matthew G.; Miller, Brandon C.; Kassu, Mintesinot; Smith, Kenneth P.; Fetigan, Andrew D.; Guo, Jason J.; Kirby, James E.; Manetsch, Roman published an article in 2022, the title of the article was The convergent total synthesis and antibacterial profile of the natural product streptothricin F.Reference of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate And the article contains the following content:
A convergent, diversity-enabling total synthesis of the natural product streptothricin F has been achieved. Herein, authors describe the potent antimicrobial activity of streptothricin F and highlight the importance of a total synthesis that allows for the installation of practical divergent steps for medicinal chem. exploits. Key features of synthesis include a Burgess reagent-mediated 1,2-anti-diamine installation, diastereoselective azidation of a lactam enolate, and a mercury(II) chloride-mediated desulfurization-guanidination. The development of this chem. enables the synthesis and structure-activity studies of streptothricin F analogs. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Reference of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate
The Article related to streptothricin f convergent total synthesis antibacterial, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Reference of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate
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